Breast cancer affects 13,500 Australian women annually, and despite gains of past decades, remains an intractable disease. Bold new approaches are required for women for whom available treatments currently offer little hope.
The NRBC (Nuclear Receptors in Breast Cancer) project is focussed on signalling pathways of nuclear receptors, which are master regulators of virtually every aspect of life. Although many nuclear receptors are expressed in breast cancers, their significance in breast cancer management has received little attention to date. The objectives of this discovery research program are
This research program is an Australia-wide collaboration between the:
It brings together established research groups from renowned research Institutes and with currently non-overlapping, internationally recognised programs of research in nuclear receptor biology. The Chief Investigators are drawn from virtually every state in Australia and contribute complementary expertise in basic hormone research, bioinformatics, high throughput analyses, human tissue research, animal models, and clinical endocrinology.
The NRBC project has been funded by a National Collaborative Research Program Grant from National Breast Cancer Foundation.